Location: Emory University School of Medicine Woodruff Circle NE, Room 190P, Atlanta, GA 30322
Nigel Pedersen, MD, Assistant Professor (Neurologist/Epileptologist) in the Department of Neurology at Emory University, will be speaking on "Chemogenetic Dissection of Hypothalamic Neural Circuits Involved in Arousal and Epilepsy.”
Summary: The mammillary and supramammillary region both influence the hippocampus. Using chemo- and optogenetic techniques, we were able to understand precise neural circuits and cell groups that innervate the hippocampus from the mammillary region, and additionally found a long-sought wake-promoting neuronal population of the caudal hypothalamus and promotes wakefulness and activates the hippocampus. Neuroanatomical tracing reveals this as a novel node of the ascending arousal network. Relevance to behavior, state control and the control of hippocampal excitability will be discussed.
John Willie, MD PhD, is an Assistant Professor (Neurosurgeon) in the Department of Neurosurgery at Emory Universitywill be speaking on "Neuromodulation of Emotion and Memory in Epilepsy Neurosurgery Patients: a framework for exploring novel brain stimulation therapies."
Summary: Epilepsy patients routinely undergo placement of electrodes into diverse brain networks for seizure monitoring. The same subjects can be used to test the effects of brain stimulation on these networks to test novel therapeutic targets. We are actively determining the effects of acute stimulation of the amygdala and other limbic structures on emotion, mood, and cognition.